Fri Mar 24 2023

67 articles - From Friday Mar 17 2023 to Friday Mar 24 2023

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

Gut

Australian inflammatory bowel disease consensus statements for preconception, pregnancy and breast feeding.

These consensus statements provide up-to-date, comprehensive recommendations for the management of pregnancy in patients with IBD. This will enable a high standard of care for patients with IBD across al clinical settings.

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Meta-analysis

meta-analyses and systematic reviews


Original articles

RCT, clinical trials, retrospective studies, etc…

Aliment Pharmacol Ther

Type 1 diabetes and microscopic colitis: A nationwide matched case-control study in Sweden.

T1D diagnosis was almost 80% more prevalent in MC patients compared to general population. This positive association did not seem to be spurious due to residual confounding shared by full siblings but may relate to consumption of medications associated with MC onset.

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Am J Gastroenterol

A Review of the Cardiovascular Safety of Prucalopride in Patients with Chronic Idiopathic Constipation.

In a real-world European CV safety study among 35,087 patients (prucalopride, 5,715; polyethylene glycol 3350 [PEG3350], 29,372), results were consistent for no evidence of increased risk of major adverse CV events among patients treated with prucalopride vs PEG3350 (incidence rate ratio = 0.64 [95% CI: 0.36-1.14]). Studies to date have not raised concerns regarding the impact of prucalopride treatment on CV parameters.

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Assisted Reproductive Technology Treatment Outcomes in Women with Liver Disease.

To our knowledge, this study is the largest to date to evaluate IVF efficacy in women with LD. Our study demonstrates that patients with LD have similar ART treatment outcomes compared to those without LD.

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CS-iCCA; A New Clinically Based Staging System for Intrahepatic Cholangiocarcinoma: Establishment and External Validation.

The proposed independently-validated staging system uses non-histopathologic data to successfully stratify patients into four stages. This staging system has better prognostic accuracy compared to the TNM staging and can assist physicians and patients in treatment of iCCA.

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Electronic Health Record Burden Amongst Gastroenterology Providers Associated with Sub-specialty and Training.

IBD and hepatology specialists and NPPs may have disproportionally high EHR burden. More work is needed to understand differences in provider workload to combat burnout.

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History of gestational diabetes and incident nonalcoholic fatty liver disease: The Kangbuk Samsung Health Study.

A prior history of GDM is an independent risk factor for NAFLD development. Insulin resistance, measured by HOMA-IR, and development of diabetes each explained only <10% of the association between GDM and incident NAFLD.

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Hybrid, high-dose dual and bismuth quadruple therapies for first-line treatment of Helicobacter pylori infection in Taiwan: a multicenter, open-label, randomized trial.

pylori infection in Taiwan. However, high-dose dual therapy has fewer adverse effects than hybrid bismuth quadruple therapies.

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Patients With Compensated Hepatitis B Virus-Related Cirrhosis and Low-Level Viremia: Treat or Not to Treat?

The current study, which analyzed data of a historical cohort of 627 patients from a single Korean center with hepatitis B virus-related compensated cirrhosis, reported a 2.4-fold increased hepatocellular carcinoma risk among patients with low-level viremia compared with those with undetectable viremia provides indirect evidence in support of treatment for this population. The study underscores the importance of treating patients before the development of cirrhosis and the need for finite duration curative therapy.

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Prevalence of minimal hepatic encephalopathy in patients with liver cirrhosis: a multicenter study.

The prevalence of MHE in patients with cirrhosis was high but varied substantially between diseases stages. These data may pave the way for more individualized MHE screening approaches.

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Clin Gastroenterol Hepatol

aMAP score and its combination with liver stiffness measurement accurately assess liver fibrosis in chronic hepatitis B patients.

AMAP score is a promising non-invasive tool for diagnosing fibrosis in CHB patients. The aMAP-LSM model could accurately estimate fibrosis stage for treated CHB patients.

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Endosc Int Open

Endoscope reprocessing: Retrospective analysis of 90,311 samples.

This study demonstrates that additional efforts, including implementation of microbial surveillance strategies using a standardized sampling method and periodic observational audits, must be made to improve the overall microbiological quality of endoscopes and reduce the risk associated with their use.

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Endoscopy

Endoscopic full-thickness plication for the treatment of gastroesophageal reflux after peroral endoscopic myotomy: a randomized sham-controlled study.

There were no major adverse events in either group. CONCLUSION : EFTP improved post-POEM GERD symptoms, 24-hour pH impedance findings with normalization in one-third, and reduced PPI usage at 6 months.

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Gastroenterology

Onco-microbial community profiling identifies clinico-molecular and prognostic subtypes of colorectal cancer.

OCS classification stratified CRCs into three distinct subgroups with different clinico-molecular features and outcomes. Our findings provide a framework for a microbiota-based stratification of CRC to refine prognostication and to inform the development of microbiota-targeted interventions.

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Gastrointest Endosc

Detection and endoscopic classification of intraductal neoplasms of the bile duct by peroral cholangioscopy with narrow-band imaging (with videos).

POC with NBI can be useful for the detection of IN-Bs. Our novel classification system based on both surface structure and microvascular pattern may allow differentiation of IN-B from ISL-Bs.

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Hepatology

Emerging targets for therapy in ALD: lessons from NASH.

However, pathways such as gut microbiome changes, glucose metabolism and insulin resistance, inflammatory signaling, and micro-RNA abnormalities are distinct in these two diseases. In this review article, we describe conserved and distinct pathogenic pathways highlighting therapeutic targets which may be of potential in both diseases, and those which are unique to each disease.

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Gut microbial metabolite butyrate improves anticancer therapy by regulating intracellular calcium homeostasis.

In conclusion, our findings provide new insight into the mechanism by which the gut microbial metabolites inhibit HCC progression, suggesting a translatable therapeutics approach to enhance the clinical targeted therapeutic efficacy.

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MELD 3.0 for adolescent liver transplant candidates.

The discriminative ability of MELD 3.0 to rank adolescents according to the risk of death within 90 days was robust. Although MELD 3.0 was initially developed and validated in adults, MELD 3.0 may also improve the prediction of waitlist mortality in adolescents and better represent their urgency for liver transplant.

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Parathyroid hormone receptor-1 signaling aggravates hepatic fibrosis through upregulating cAMP response element binding protein-like 2.

In both mouse and human models, we found that PTH1R was highly expressed in activated HSCs and fibrotic liver. PTH1R signaling regulated collagen production in the HSCs via Crebl2/SMAD3/TGFß regulatory circuits. Blockade of PTH1R signaling in HSCs might help mitigate the development of liver fibrosis.

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Sepsis induced endothelial dysfunction drives acute-on-chronic liver failure via Angiopoietin-2-HGF-C/EBPß pathway.

The transcription factor C/EBPß is activated in both mouse and human ACLF and is a potential therapeutic target to prevent liver failure in patients with sepsis and cirrhosis.

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J Hepatol

A 3-Year Course Of Bulevirtide Monotherapy May Cure Hdv Infection In Cirrhotics.

In the off-therapy liver biopsy, intrahepatic HDV RNA and Hepatitis D antigen were undetectable, <1% hepatocytes were Hepatitis B surface antigen positive while hepatitis B core antigen was negative. Grading and staging improved compared to pre-treatment biopsy.

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Risk of parenterally transmitted hepatitis following exposure to invasive procedures in Italy: SEIEVA surveillance 2000-2021.

Despite the progress made in recent years, invasive procedures still represent a significant risk factor for acquiring parenterally transmitted hepatitis viruses, thus explaining the still numerous and unexpected cases diagnosed among the elderly population in Italy. Our results underline the importance of observing universal precautions to control the iatrogenic transmission of hepatitis viruses. Impact and implications Cases of parenterally transmitted acute viral hepatitis in the elderly population, that are difficult to explain by the most recognized risk factors, continue to bde diagnosed in Italy. Based on the Italian SEIEVA surveillance of acute viral hepatitis data, the study highlights an increased risk of acquiring hepatitis B and C following exposure to invasive procedures, which might explain the cases in elderly individuals. Furthermore, this finding emphasises the need to observe universal precautions strictly, in healthcare settings, also in case of minor surgery procedures.

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Neurogastroenterol Motil

Self-reported gastrointestinal disorders among veterans with gulf war illness with and without posttraumatic stress disorder.

GW veterans with GWI and PTSD have significantly higher odds of specific self-reported GI disorders than the other groups. Given the known bidirectional influences of the gut and brain, these veterans may benefit from a holistic healthcare approach that considers biopsychosocial contributors to the assessment and management of disease.

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The ghrelin agonist, HM01 activates central vagal and enteric cholinergic neurons and reverses gastric inflammatory and ileus responses in rats.

and inference Peripheral HM0 activates central vagal and myenteric cholinergic pathways that may influence both central and peripheral targets to prevent AS-induced gastric inflammatory and ileus.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Clin Gastroenterol Hepatol

Development of a practical guide to implement and monitor diet therapy for eosinophilic esophagitis.

Without standardized guidance on starting or completing the diet for GI providers and/or consulting dietitians, provider attitudes towards dietary therapy vary greatly depending on familiarity and knowledge gaps in using diet therapy. This review aims to summarize evidence in support of dietary therapy in EoE while providing guidance on initiation and implementation of dietary therapy for providers.

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Gut

Ten reasons gastroenterologists and hepatologists should be treating obesity.

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J Hepatol

Combination immunotherapy for hepatocellular carcinoma.

These include choice and sequencing of treatments, identification of biomarkers, combinations with locoregional therapies, and development of new immunotherapy agents. This review summarizes the scientific rationale and available clinical data for combination immunotherapy in advanced HCC.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Am J Gastroenterol

Guide to Intestinal Ultrasound Credentialing, Documentation, and Billing for Gastroenterologists in the United States.

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How to prevent and treat the most frequent adverse events related to luminal dilation and stenting in benign disease.

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Underwater anti-reflux mucosectomy for refractory gastroesophageal reflux disease:A rapid and simple technique for endoscopic treatment.

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Clin Gastroenterol Hepatol

Health Advocacy, Policy, and Legislation for GI Practices.

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How to Manage Targeted Immune Suppressants (Biologics and Oral Small-molecule Drugs) Perioperatively for Inflammatory Bowel Disease and non-Inflammatory Bowel Disease surgery.

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Quality Improvement Training for Gastroenterology and Hepatology Fellowship: More Than Just a GME Requirement.

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Splenic Arteriovenous Fistula Coexisting with Spontaneous Splenorenal Shunt in A Cirrhotic Patient.

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Endoscopy

Double trouble during peroral endoscopic myotomy for achalasia cardia: myotomy to the rescue.

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Early gastric mucosa-associated lymphoid tissue lymphoma treated by endoscopic submucosal dissection.

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Endobiliary radiofrequency ablation of an intraductal vessel in a patient with surgically altered anatomy.

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Endoscopic resection of a gastric gastrointestinal stromal tumor without perforation using a detachable snare.

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Endoscopic transgastric extraction of a prophylactic pancreatic single-pigtail plastic stent that had previously migrated into the caudal part of the Wirsung duct.

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Gel immersion endoscopic papillectomy using a double-balloon endoscope to resect an ampullary tumor.

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Hemostasis using a large spherical electrode device for bleeding due to endoscopic sphincterotomy.

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High quality Barrett's endoscopy: inspection time is a critical component.

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Off-label use of novel hemostatic gel to treat wound dehiscence after stapled hemorrhoidectomy.

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Removal of an impacted migrated biliary stent with cholangioscopy: lights, camera, action.

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Successful hemostasis of multiple parapapillary diverticular hemorrhage by clip-with-rubber-band traction technique at the descending duodenum.

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Successful hemostasis using a self-assembling peptide hydrogel for bleeding after endoscopic papillary large-balloon dilation.

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Successful treatment using balloon-assisted enteroscopy for jejunal loop variceal bleeding after pancreaticoduodenectomy.

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Use of a traction device facilitates opening of the pocket during the pocket-creation method of gastric endoscopic submucosal dissection.

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Gastroenterology

Can microbes and their components prevent growth failure caused by malnutrition?

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Disposable Elevator Caps Reduce Microbial Contamination after ERCP.

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Impact of Screening-related Sigmoidoscopy on the Incidence and Mortality of Colorectal Cancer.

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Is the Quantification of Interstitial Cells of Cajal in Gastric Biopsies in Patients with Gastroparesis Ready for Prime Time?

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Molecular profile of MSH6-associated colorectal carcinomas shows distinct features from other Lynch syndrome-associated colorectal carcinomas.

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Hepatology

Intestinal dendritic cells, gatekeepers preventing ethanol-induced liver disease.

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Letter to editor: Association between birth weight, preterm birth, and nonalcoholic fatty liver disease in a community-based cohort.

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Letter to Editor: Influence of maternal NAFLD on infant weight-the real precursor to NAFLD in offspring?

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Letter to the editor: hepatic interferon regulatory factor 8 expression suppresses hepatocellular carcinoma progression and enhances the response to anti-programmed cell death protein-1 therapy.

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Letter to the Editor: Hepatic steatosis and glycemic burden in chronic hepatitis B.

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Letter to the Editor: the associations between hepatic steatosis and incident cardiovascular disease and all-cause mortality.

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Preventing two viral infections with one tablet.

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Reply: hepatic steatosis and glycemic burden in chronic hepatitis b.

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Reply: The associations between hepatic steatosis and incident cardiovascular disease and all-cause mortality.

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Treatment of autoimmune hepatitis: Budesonide does not solve our problems.

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J Hepatol

An infrequent cause of spontaneous liver rupture.

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From the Editor's Desk...

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Letters&Replies

Letters to the editors and authors’ replies

Aliment Pharmacol Ther

Letter: Low to moderate alcohol intake and progression of non-alcoholic fatty liver disease.

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J Hepatol

Letter to the Editor: An isolated insular stroke mimics a bout of overt hepatic encephalopathy in a patient with cirrhosis.

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